630559, Koltsovo village, Novosibirsk region

tel: (3832) 36-60-10

fax: (3832) 36-74-09

e-mail:

http://www.vector.nsc.ru

State Scientific Center for Virology and Biotechnology "Vector" (SSC VB "Vector") is one of the largest research and production complexes in Russia. The main activities of the Center are conducting fundamental research in a wide field of natural sciences and the development and production of therapeutic, preventive and diagnostic drugs.

Fundamental research work of the Center is focused on obtaining new scientific knowledge in the field of molecular biology, virology, genetic engineering, biotechnology, epidemiology and ecology in order to use it in the interests of the national economy.

The history of the formation of the SSC VB "Vector" begins in 1974, when the head institute of the Center at that time, the All-Union Scientific Research Institute of Molecular Biology, was formed. In 1985, the Research and Production Association "Vector" was created on its basis, which received the status of a State Scientific Center in 1994.

Currently, the State Scientific Center for Virology and Biotechnology "Vector" unites a number of research institutes, production structures and other organizations. In addition, the Center is an associated member of a number of associations.

The main asset of the Center is a unique laboratory and experimental base, which has no analogues in Russia, which allows research with viruses pathogenic for humans and animals in complete safety for personnel and the environment. Highly qualified engineering, technical and scientific personnel have extensive experience working with particularly dangerous viruses in the field of virology, molecular biology, genetic and cellular engineering, biotechnology, ecology and epidemiology.

As of April 1, 2000, the Center employs 1,842 employees, of whom 901 are engaged in scientific research, including 17 doctors and 147 candidates of science.

The training of highly qualified personnel is provided by the postgraduate school created at the Center in 1983, open in three specialties: molecular biology, virology and biotechnology. The SSC VB "Vector" has a dissertation council (D 208.020.01), in which 19 doctoral and 129 candidate dissertations were defended in the above specialties.

One of the Center’s tasks is to provide the Novosibirsk region with drugs from donor blood, including anti-tick immunoglobulin. In close contact with city clinics, work is underway to diagnose a number of infectious diseases (viral hepatitis A, B, C, D, AIDS, cytomegalovirus, herpes and toxoplasma infections) and to expand the scope of use of antiviral drugs developed at the State Research Center for Virus and Virology "Vector".

Over the past years, the Novosibirsk administration has been financing a number of innovative projects of the State Research Center for Virology and Biochemistry "Vector" related to the development of immunobiological and medical drugs.

History of SSC VB "Vector"

1974 - Based on the Government Decree on the development of molecular biology and biotechnology, by order of the Main Directorate of Microbiological Industry under the Council of Ministers of the USSR (No. 1683 of 08/02/74), the All-Union Scientific Research Institute of Molecular Biology (VNII MB) was formed. The main task assigned to the Institute in those years was to study the fundamental features of the structure and function of especially dangerous viruses (VDV), experimentally study the pathogenesis of VDV, study the natural variability of specific viruses based on the analysis of the primary structure of their isolates obtained from different regions of the world, with the purpose of predicting the possibility of the emergence of new pathogens pathogenic for humans. In terms of application, the All-Russian Research Institute of MB was tasked with developing vaccine and diagnostic drugs using the latest achievements of genetic engineering.

The All-Union Production Association "Biopreparat" made a decisive contribution to the creation and organization of the All-Union Research Institute of Medical Sciences. With the direct participation of professors V.I. Ogarkova, V.D. Belyaeva, Yu.T. Kalinina, A.A. Vorobyova, I.V. Nikonova, L.A. Klyucharev created the laboratory and experimental base of the All-Russian Scientific Research Institute of Medical Sciences.

The Siberian Branch of the USSR Academy of Sciences played an important role in the creation and development of the All-Russian Research Institute of Medical Sciences. Academicians M.A. took a great part in its organization. Lavrentiev, G.I. Marchuk, D.K. Belyaev, D.K. Knorre. The VNII MB was provided with temporary space in Akademgorodok, where during the first 4 years scientific work was carried out in close collaboration with the Novosibirsk Institute of Bioorganic Chemistry, the Institute of Organic Chemistry, and the Institute of Cytology and Genetics. These close scientific ties have continued to this day.

1985 - The research and production association "Vector" (NPO "Vector") was created, which included VNII MB, NIKTI BAV (Research Design and Technological Institute of Biologically Active Substances), OPSP (Experimental Production Agricultural Enterprise) and NOPB (Scientific Experimental Industrial Base).

1994 - By Decree of the Government of the Russian Federation of March 29, 1994 No. 247, NPO "Vector" was awarded the status of a state scientific center of the Russian Federation - the State Research Center of Virology and Biotechnology "Vector". Order of the Ministry of Health and Medical Industry of the Russian Federation dated October 21, 1994 No. 210 approved the Charter of the state federal enterprise State Scientific Center for Virology and Biotechnology "Vector" of the Ministry of Health and Medical Industry of the Russian Federation.

1998 - Order of the Ministry of Health of the Russian Federation dated February 12, 1998 No. 40 approved changes and additions to the Charter of the State Unitary Enterprise State Scientific Center for Virology and Biotechnology "Vector" of the Ministry of Health of the Russian Federation.

1999 - Received a certificate from the Ministry of Science and Technology of the Russian Federation on state accreditation of the scientific organization State Unitary Enterprise State Scientific Center of Virology and Biotechnology "Vector" of the Ministry of Health of the Russian Federation dated April 22, 1999, No. 1091.

Currently, the State Scientific Center for Virology and Biotechnology "Vector" is a large research and production complex, including six research institutes, four subsidiaries, a branch (NIKTI BAV) and a number of other separate structural divisions.

Structure of SSC VB "Vector"

Research Institute of Molecular Biology

(Director - Corresponding Member of the Russian Academy of Sciences, Doctor of Biological Sciences, Professor S.V. Netesov)

• Fundamental and exploratory research in the field of classical and molecular virology, aimed at obtaining new scientific knowledge with the subsequent prospect of its use in the development of therapeutic, preventive and diagnostic drugs for the needs of healthcare and veterinary medicine.
• Study of the molecular diversity of human and animal viruses.
• Study of the evolution of the most dangerous viral pathogens of humans and animals, incl. at the molecular level, and development of methodology for monitoring viral diseases.
• Molecular epidemiological studies of transmission routes of viral infections.
• Applied research on the development of therapeutic, diagnostic and preventive drugs for medicine and veterinary medicine.
• Study of the mechanisms of functioning of genomes and proteins of pro- and eukaryotes.

Research Institute of Bioengineering

(Director - Doctor of Biological Sciences, Professor A.A. Ilyichev)

Main activities:

• Construction of heterologous gene expression systems in microbial cells to create on their basis producers of proteins of biomedical interest.
• Creation of protein variants with improved properties using protein engineering methods for their production and use in medical practice.
• Using phage display technology to map antigenic determinants of viral proteins, obtain functional mimetics of antigenic determinants, and construct recombinant antibodies against human and animal pathogens.
• Development of principles and methodological approaches for designing vaccines against viral diseases.
• Development of diagnostic test systems, including those based on molecular hybridization and nucleic acid amplification for use in medicine and veterinary medicine.
• Study of the structural and functional organization of viral genomes of farm animals.
• Study of the mechanisms of implementation of the biostimulating and repair effects of chitosan at the cellular level.
• Organization of production of chitogel preparations on the basis of the State Research Center for Virology and Biochemistry "Vector".
• Studying the interaction of recombinant filamentous phages with cell surface receptors with the aim of selecting recombinant variants that specifically interact with cancer cells.
• Using phage display technology to diagnose the early stages of atherosclerosis.
• Development of methods for rapid determination of M. tuberculosis resistance and investigation of the causes of its occurrence.
• Study by molecular biological methods of M. tuberculosis isolates circulating in the West Siberian region and creation of their representative collection.
• Study of factors influencing the effectiveness of tuberculosis immunoprophylaxis and identification of possible ways to improve the vaccine.

Research Institute "Collection of Cultures and Microorganisms"

(Director - Candidate of Biological Sciences V.E. Repin)

Main activities:

• Isolation, typing and storage of viral and bacterial strains, strains of producers of biologically active substances, genetically marked strains and genetic constructs obtained in domestic and foreign laboratories.
• Studying the properties of newly obtained strains, including genetically modified variants of previously known strains; their certification, including using the method of genomic fingerprinting; deposit and storage.
• Obtaining strains of microorganisms for use in environmental interests.
• Development of technology for the production of viral, bacterial and fungal entomopathogenic drugs.
• Maintaining and studying the national collection of variola virus strains.

Research Institute of Cell Cultures

(Director - Candidate of Medical Sciences E.A. Nechaeva)

Main activities:

• Replenishment and maintenance of a bank of cell cultures of vertebrates, insects and plants, certification of lines and strains.
• Obtaining and certification of new lines and productive clones.
• Receipt and storage of seed and working banks of cell cultures producing biologically active substances, their certification in accordance with WHO requirements.
• Providing pilot industrial developments, research and experimental work at the State Research Center for Virology and Biochemistry "Vector" with continuous and primary cell cultures.
• Development and implementation of new technologies for the production of medicines using cell engineering technology.
• Development, improvement and implementation of new technologies for the preparation of vaccine preparations using cell cultures and ways of delivering the vaccine to a living organism; development of new forms of their application.
• Development of technology for obtaining human cells for skin restoration.
• Development of technology for the production of hyaluronic acid.
• Production of live measles vaccine.
• Production of nutrient media for the cultivation of cells and viruses.
• Production of "Gemovect" solutions for use in hemodialysis and "Transvect" for storing transplants.
• Production of blood serum from cattle and horses.

Research Institute of Aerobiology

(Director - Candidate of Technical Sciences V.S. Toporkov)

The main activities of the Institute are related to fundamental and applied research in the field of ecology, medicine and healthcare. The Institute conducts bioaerosol research in the interests of medicine, virology and ecology. We are also developing modern technologies for obtaining therapeutic, prophylactic and diagnostic drugs for the needs of healthcare and veterinary medicine, and developing new instrumental methods for studying biological and bioaerosol systems. Research areas include:

• theoretical and experimental study of the distribution of aerosol pollution and bioaerosols in the atmosphere, their impact on public health and the development of preventive measures for areas with an unfavorable environmental situation;
• development of new methods and means of specific prevention;
• development of new types of samplers and equipment for identifying the biogenic component in aerosol impurities;
• development of new methodological approaches for express diagnostics of the sensitivity of microorganisms to allergens and drugs.

WHO Collaborating Center for the Diagnosis of Orthopoxvirus Infections and Museum of Smallpox Virus Strains and DNA

(supervisor - Academician of the Russian Academy of Sciences, Doctor of Biological Sciences, Professor L.S. Sandakhchiev)

Laboratory Animal Nursery

(director - V.N. Bondarenko)

Subsidiaries:

Subsidiary state unitary experimental production enterprise "Vector-BiAlgam"

(director - L.G. Nikulin)

"Vector-BiAlgam" is one of the leading enterprises in the field of development and production of immunobiological products and bifid-containing drugs and products.

• More than 20 dairy industry enterprises operate using Vector-BiAlgam technologies, including Siberian Milk LLC (Novosibirsk), Siberian Dairy Company LLC (Kemerovo);
• A new promising strain of bifidobacteria has been patented in Russia and confirmed by a Eurasian patent;
• By orders of the Ministry of Health of the Russian Federation, the Ministry of Justice of the Russian Federation and the Ministry of Internal Affairs of the Russian Federation, supplies of hepatitis A vaccine are carried out;
• As part of the new project, a mini-factory is being built to produce bifid-containing baby food;
• A divaccine for hepatitis A and B has been developed and is undergoing clinical trials.

Subsidiary state unitary production enterprise "Vector-Pharm"

(Director - Candidate of Physical and Mathematical Sciences S.N. Targonsky)

Main activities:

• Production of therapeutic and diagnostic drugs developed at the Center.
• Launching the production of healthcare products using technologies developed by third parties.
• Production of finished dosage forms in cooperation with foreign firms and companies.
• Storage and sales of products produced by the Center.

Subsidiary state unitary experimental production agricultural enterprise "Vector-OPSP"

(director - D.N. Loktionov)

Main activities:

• Development of technology for growing medicinal herbs.
• Breeding deer to produce antlers.
• Creation of an experimental base for obtaining cattle whey.
• Preparation of feed for keeping laboratory animals.

Branches operating on the basis of regulations

Research Design and Technology Institute of Biologically Active Substances (NIKTI BAV)

(Director - Doctor of Biological Sciences V.I. Masycheva)

Main activities:

• Creation of methods for obtaining products of modern biotechnology: recombinant cytokines and mutant versions of recombinant proteins, nucleic acids.
• Conducting preclinical tests of drugs for medical and veterinary purposes.
• Development of technologies for obtaining substances and dosage forms for the prevention and treatment of immunodeficiency, cancer and infectious diseases of humans and animals.
• Creation of molecular constructs for targeted delivery of protein and genetic material.
• Development of diagnostic test systems for identifying infectious diseases.

(FBU SSC VB “Vector”)

brief information

One of the largest virological and biotechnological centers in Russia. Fundamental research work is focused on obtaining new scientific knowledge in the field of molecular epidemiology, molecular biology, genetic and cellular engineering, biotechnology, nanobiotechnology, ecology and biological safety. Applied research is aimed at developing effective means and methods for the prevention, treatment and diagnosis of infectious diseases. Since 1997, the WHO Collaborating Center for the Diagnosis of Orthopoxvirus Infections and a museum of variola virus strains and DNA have been operating on the basis of the State Scientific Center for Virology and Biochemistry “Vector”. Since 2009, the WHO reference laboratory for diagnosing H5 influenza, the only one in Russia and one of 13 in the world, has been operating on the basis of the State Scientific Center for Virology and Biotechnology “Vector”.

The mission of the Center is scientific and practical support for countering global biological threats.

Founded (created)

The center was founded in 1974. In 1994, by Decree of the Government of the Russian Federation of March 29, 1994 No. 247, it was awarded the status of the State Scientific Center of the Russian Federation, confirmed to date by the relevant regulations of the Government of the Russian Federation (1997, 2000, 2002, 2004, 2007, 2009, 2011, 2013).

Work on priority areas and critical technologies for the development of science, technology and engineering

Work is carried out in priority areas of science, technology and engineering of the Russian Federation: “Security and countering terrorism”, “Science and life” and in critical technologies: “Biocatalytic, biosynthetic and biosensor technologies”, “Biomedical and veterinary technologies”, “Genomic, proteomic and postgenomic technologies”, “Cell technologies”, “Nano-, bio-, information, cognitive technologies”, “Bioengineering technologies”.

Participation in the implementation of technology platforms

FBU SSC VB “Vector” is a member of the Technology Platform “Medicine of the Future” and the Technology Platform “Environmental Development Technologies”.

Innovative projects

Multiplex test systems for identifying infections transmitted through tick and mosquito bites, multiplex test systems for identifying more than 10 intestinal infections, cultural, recombinant and DNA vaccines against socially significant and especially dangerous viral diseases, including variola virus, polyepitope vaccines against HIV/AIDS and other infectious diseases of humans and animals, new methods of delivering vaccines and drugs (tablets, microencapsulated, nanomicroencapsulated), antiviral and antitumor drugs, new methods for the differential diagnosis of somatic diseases using dielectrophoresis, mathematical models of the spread of epidemics of infectious diseases.

Research experimental base

A unique scientific and experimental base for conducting research with the most dangerous viruses to humans, including those for which there is no treatment or specific prevention, in complete safety for working personnel and the environment. Modern equipment for molecular biological, diagnostic, biotechnological, aerosol research. Availability of a site for the production of vaccine preparations, a site for the production of culture media, measles vaccine in accordance with GMP requirements, as well as pilot sites for the production of pilot batches of vaccine and medicines under development.

Patents, certificates

178 valid patents of the Russian Federation, 4 utility models, 20 certificates.

Number of personnel engaged in research and development

Availability of Agreements with higher educational institutions

Novosibirsk Medical University;

Novosibirsk State University;

Altai State University;

Novosibirsk State Agrarian University;

National Research Tomsk Polytechnic University.

Basic departments, scientific schools

The Center has four leading scientific and pedagogical schools: microbiology, immunology and virology, genetic engineering, biotechnology. There is an agreement with Altai State University on the creation of a basic department of “biopharmaceuticals based on recombinant technologies.”

Main partners

Carries out scientific cooperation with institutions of the Russian Academy of Sciences, SB RAS, RAMS, SB RAMS, SB RAAS, research institutions of Rospotrebnadzor, with the State Scientific Center of the Russian Federation, higher educational institutions and pharmaceutical enterprises.

International scientific and technical cooperation

Cooperation:

With WHO influenza as a member of the WHO Global Influenza Surveillance and Response System;

With WHO as experts on the WHO Advisory Committee on the Study of Variola Virus;

With the Centers for Disease Control and Prevention (CDC, Atlanta, USA); - with the WHO Reference Laboratory for influenza H5 subtype (Hong Kong, China);

With the WHO Collaborating Center for the Study of the Ecology of Influenza in Animals and Birds (Memphis, USA);

WHO Collaborating Center for Reference Diagnostics and Research on Influenza (London, UK);

With the Northwestern Institute of Biology Plateau of the Chinese Academy of Sciences, with the Beijing Institute of Biological Sciences of the Chinese Academy of Sciences, with the Institute of Immunology of the Academy of Sciences of the Republic of Uzbekistan, with the national influenza centers of the CIS countries (Kazakhstan, Kyrgyzstan, Azerbaijan, Belarus, Uzbekistan, Tajikistan).

Since August 2014, in the Republic of Guinea, as part of the ongoing work to assist West African countries in the fight against Ebola virus disease (EVD), a Russian laboratory began operating on the basis of a mobile complex of a specialized anti-epidemic team of Rospotrebnadzor.