home Translator Structure of the assortment of dietary supplements in a research pharmacy. Results of our own research

Structure of the assortment of dietary supplements in a research pharmacy. Results of our own research

Starting the analysis, let’s identify the main dietary supplements contained in the pharmacy’s assortment.

The assortment also includes drugs from such manufacturers as ArtLife, Altai Cedar, AKVION, LEOVIT nutrio, Parapharm, Balsam, Vitalain, Herbs of Baikal, Pharmakor, Fitogalenika.

Let us present below the seasonal sales schedule for dietary supplements for 2013.

Figure 15 - Seasonal sales chart of dietary supplements for 2013

Thus, the highest sales in 2013 were recorded in May, September, October and December. Lowest sales were observed in February, August, November.

Let us turn to the analysis of the position of a pharmacy organization in the pharmaceutical market of the city of Voronezh.

The pharmacy organization is located in a fairly public place, its customers are approximately 57% regular consumers living or working nearby, the rest are non-regular customers. The pharmacy is part of a pharmacy chain that is very well known in Russia and has a reliable reputation, which has a positive effect on the consumer’s choice of this particular pharmacy.

Sales of a pharmacy organization were analyzed above, without division into assortment groups; let us now consider the structure of the assortment of dietary supplements.

Let us present the assortment of dietary supplements and calculate the indicators of the structure of the assortment of dietary supplements of a pharmacy organization in the table below.

Table 16 - Structure of the assortment of CJSC Melodiya Zdorovya for 2013.

Product group (by dietary supplement type)	Number of product items	Turnover by product group	Share in turnover, %

For the cardiovascular system
Tonic
Calming
Immuno-strengthening
For children
General restorative drugs
For weight loss
For the respiratory tract
Hepatoprotectors
Men's health products
			100 (current turnover Pharmacy organization in 2013 amounted to 56,984 thousand rubles, Therefore, dietary supplement They occupy 18.22% of the total turnover)

The table shows that the largest specific gravity in circulation are general strengthening drugs (33%). The smallest share in turnover is made up of drugs for the gastrointestinal tract - 1.5%, as well as hepatoprotectors - 2.8%

The pharmacy organization's assortment of dietary supplements includes 1,800 items.

In 2012 three inspections were carried out by a higher organization (the pharmacy organization is part of the pharmacy chain), which showed that a certain number of goods provided for in the assortment list were not on sale.

Let's calculate the stability indicator of the assortment of dietary supplements of a pharmacy organization.

K y = 1-((12+5+14+10+5+13+21+11+6+9+21)/ 1800*3)=0.79

The stability coefficient is 0.79%, while the average normative meaning coefficient - 0.9.

Products are purchased one by one product groups strictly periodically, for others - as needed, based on the uneven demand for these goods, it is also possible to purchase dietary supplements “to order” with an advance payment made by the consumer. The purchase of goods is carried out on the basis of warehouse data, where computer records of inventory items are kept.

The information base allows you to quickly and accurately reflect the receipt and consumption of drugs in the program, which allows management at any time to receive reliable information about the balance of drugs in the pharmacy and warehouse and make purchasing decisions. Goods are purchased in relatively small quantities, taking into account the expected sales volume and the structure of customer demand.

The pharmacy organization purchases drugs, including dietary supplements for subsequent retail sales at wholesale suppliers, with the exception of the three main manufacturers of dietary supplements (Evalar, ArtLife and Vitalayn). The purchase of goods from suppliers is carried out on the basis of purchase and sale contracts, which are concluded in a simple writing and certified by the signatures and seals of the parties. The subject of these agreements is the purchase and sale of goods, the parties are the Seller and the Buyer. A standard purchase and sale agreement with suppliers for organizations of the Melodiya Zdorovya pharmacy chain contains the following basic conditions - the moment of transfer of ownership of the goods to the Buyer, the purpose of purchasing the goods, assortment, quantity, price of the goods and payment procedure, quality of the goods and delivery conditions, deadline validity of the agreement, as well as details of the parties. When determining the assortment, quantity and price of the purchased goods, the parties to the contracts refer to price agreement protocols. Method and terms of payment: within 30 days from the date of receipt of the goods, but advance payment is also possible. According to agreements with suppliers, delivery of goods is carried out at the expense of the supplier. In case of non-fulfillment or improper fulfillment of the terms of the contract, the parties are guided by law Russian Federation. For each individual delivery under the contract, the assortment, quantity and price of goods are agreed upon in the Protocol for agreeing on the contract price for inventory items. This Protocol contains the name of the product, unit of measurement, quantity, unit price of the manufacturer, wholesale markup of the supplier, selling price and cost excluding VAT. The release of goods is carried out according to goods transport or waybills-TTN-1/TN-2, where the additional amount of VAT and the cost including VAT are indicated. Payment is carried out according to TTN/TN.

Table 18 - Dynamics of the volume of purchases of a pharmacy organization for 2011 - 2013. (thousand roubles.)

In 2012-2013, there was a slight increase in the activity of the enterprise; the volume of purchases increased by 6.19 million rubles. (6.32%) in 2012 compared to 2011. In 2013, the volume of purchases increased by 4.98%, and the overall increase, compared to 2011, was 11.61%. The largest increase occurred in purchases from ArtLife: in 2012, purchases from this supplier increased by 19.21%, and over the nine months of 2013 by another 19.13%. This growth is explained by more convenient and profitable job with this supplier, compared to others: a wide range of goods, rhythmic deliveries, price policy supplier.

Thus, the absence of violation of contractual obligations, both on the part of suppliers and on the part of the pharmacy organization, indicates a fairly effective conduct of the company’s work on the purchase of goods.

The main intention of buyers when visiting a pharmacy is to satisfy the demand for drugs, taking into account purchasing power. Providing a necessary and stable range of drugs and dietary supplements, reflecting the needs of customers, is considered a factor of paramount importance in trade services, which, of course, includes pharmacy organizations. Indicators of the targeted formation of a product range are the coefficient of steady state of the assortment, the growth of turnover and profit.

The uniformity of development of trade turnover of a trading enterprise can be analyzed in more depth using the data in the table below.

Analysis commercial activities pharmacy organization showed that the enterprise is well provided with the material and technical base: the presence of its own trading and warehouse space, trade and technological equipment allow you to organize the effective work of a pharmacy organization. The enterprise management system has a linear-functional structure.

Let us now turn to the analysis of the assortment of dietary supplements based on ABC and XYZ - product analysis.

Products A are the most important dietary supplement items, bringing the first 50% of the results;

goods B are “medium” in importance, bringing another 30% of the result;

goods C are “problem” goods that bring the remaining 20% of the result.

The analysis showed that group A includes dietary supplements for children - 16.5% of turnover, general health supplements - 33%, dietary supplements for weight loss - 19.9%. The fact that these dietary supplements were included in group A indicates customer satisfaction with these assortment groups.

DIETARY NUTRITION – NUTRITION OF A SICK PERSON AND ANALYSIS OF THE RANGE OF DIETICAL Supplements AND PRODUCTS OFFERED IN PHARMACY PRACTICEState budgetary professional educational institution
Moscow City Health Department
"Medical College No. 6"
GRADUATE WORK
DIETARY NUTRITION –
NUTRITION OF A SICK PERSON AND
ANALYSIS OF THE RANGE OF BADS AND
PRODUCTS OFFERED IN
PHARMACY PRACTICE
Completed by: Davydova I.I.
Head: Kulyanova A.E.

Goals and objectives of the thesis:

To study the approach to dietary nutrition of sick people
Make a description of dietary supplements used by patients
people while dieting
Explore the range of dietary supplements used in complex
therapy of certain pathologies,
Conduct marketing and sociological work on
demand for this type goods
Draw conclusions and develop recommendations to
improve the quality of work of the pharmacist and the pharmacy as a whole.

Diet

Diet is the rules for eating food, according to its type, quality, quantity and
time; rules for all other vital needs, for health protection,
protection, amulet. It must be observed not only in case of an insane desire
get rid of excess weight, and constantly, prolonging it in such a simple way
way of life, making the body's work easier.
© Dictionary alive
Great Russian language by Vladimir Dahl
The ancient Greek physician Asklepiades was the first to say: any disease can be
cure with the help of a properly selected diet.

Diets for various diseases of organs and systems

Diet No. 1, No. 1a, No. 1b - peptic ulcer of the stomach and duodenum
Diet No. 2 - chronic gastritis, acute gastritis, enteritis and colitis, chronic enterocolitis
Diet No. 3 - constipation
Diet No. 4, No. 4a, No. 4b, No. 4c - intestinal diseases with diarrhea
Diet No. 5, No. 5a - diseases of the liver and biliary tract
Diet No. 6 - gout, urolithiasis with the formation of stones from uric acid salts
Diet No. 7, No. 7a, No. 7b - acute and chronic nephritis (pyelonephritis, glomerulonephritis)
Diet No. 8 - obesity
Diet No. 9 - diabetes mellitus
Diet No. 10 - diseases of the cardiovascular system with circulatory failure
Diet No. 11 - tuberculosis
Diet No. 12 - functional diseases of the nervous system
Diet No. 13 - acute infectious diseases
Diet No. 14 - kidney stone disease with the passage of stones consisting mainly of
oxalates
Diet No. 15 - various diseases that do not require special diets

Assortment analysis

Having analyzed the possible range of dietary supplements used for pathologies taken on
Study during this study revealed that pharmacies can offer:
45 various drugs
in 63 dosage forms
and with 93 different dosages.
In the pharmacy - the research base, the range of these same dietary supplements showed the presence of:
16 different drugs
in 4 dosage forms
and with 16 different dosages

Assortment indicators

Ksh =
actual pharmacy assortment
basic assortment
Actual pharmacy assortment – 16 items
Basic assortment – 45 items
Ksh =

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Chapter 1. Dietary supplements and their role in human life

1.1 General classification dietary supplement

1.2 Composition of dietary supplements

Chapter 2. Regulatory and legal issues production and turnover of dietary supplements

1 Legal regulation turnover of dietary supplements

2 Production of dietary supplements

Chapter 3. Practical part

1 Analysis of the range of dietary supplements in a pharmacy organization

2 Strategy for developing an assortment of dietary supplements in a pharmacy organization

Conclusion

Bibliography

Applications

Introduction

Recent years have been characterized by the rapid development of a new field of knowledge, bordering between the science of nutrition and pharmacology, which can be called pharmaconutritiology. The prerequisites for the development of this science are, firstly, the successes of nutritionology itself, which has deciphered the role and significance of individual nutrients for human life, including the so-called micronutrients, and has proven that in economically developed countries it is practically possible to achieve optimal provision of all population groups with energy and nutrients only with widespread use of dietary supplements; secondly, the successes of bioorganic chemistry and biotechnology, which made it possible to obtain biologically and pharmacologically active components in a sufficiently purified form from almost any biosubstrate (microorganisms, plants, animals); thirdly, the successes of the pharmacological complex, which deciphered the mechanism of action and features of the biotransformation of many natural compounds and created new technologies for obtaining their effective dosage forms.

It has been established that humans are adapted to the consumption of large amounts of biologically active substances, the sources of which are representatives of more than 300 plant genera. With plant foods, a person receives the necessary nutrients, as well as vitamins and microelements. Although the clinical picture of phytocompound deficiency has not been established, their low concentration in the diet is accompanied by a significant increase in the risk of developing cardiovascular diseases, cancer, and diabetes. Some researchers even consider such diseases as manifestations of a state of maladaptation as a result of a constantly low intake of components from food that are absolutely necessary to ensure the protective and adaptive capabilities of the body. An extremely important and only reliable means of improving the nutritional structure and achieving an optimal balance in the population’s diet is the use of biologically active food additives (BAA) in the daily diet of healthy and sick people.

Relevance of the topic: unlike medicines, including biologically active substances for medicinal purposes in doses that are usually tens and hundreds of times higher than the physiological need of a healthy person, and introduced into the body both orally and parenterally, dietary supplements are used to compensate for the deficiency of these substances in the diet in quantities found in within the physiological needs of a person, and is used only orally - with food during meals.

Purpose: to study the range of biologically active food additives in pharmacies. To achieve this goal, it is necessary to solve the following tasks:

1. Study the concept of “dietary supplements” to food in human life.

2. Consider the classification of dietary supplements.

3. Determine which regulatory documents relate to dietary supplements.

4. Get acquainted with the rules for certification of dietary supplements and labeling elements.

5. Select biologically active additives in the pharmacy assortment.

The object of the study is a pharmacy organization.

The subject is the assortment of a pharmacy organization.

Research methods:

Data collection;

Classification;

Statistical analysis;

Generalization. additive

Chapter 1. Dietary supplements and their role in human life

1.1 General classification of dietary supplements

assortment of biologically active additives

Biologically active additives (BAA) are natural (identical to natural) biologically active substances intended for consumption simultaneously with food or for inclusion in a composition. food products(definition in accordance with Federal Law dated January 2, 2010 No. 29-FZ “On the quality and safety of food products)

From a legal point of view, dietary supplements are classified as food products. But dietary supplements are food products that have noticeable biological activity - the ability to influence physiological processes in the body. Note that many food substances have biological activity, and biological activity increases with increasing content of these substances in the diet.

Dietary supplements for food must be distinguished from “food additives”. This term in Russia refers to technological additives used in the food industry and in everyday life, in the production of food products and culinary products. Their full name is “food additives and excipients”. These include food colorings, preservatives, flavors, emulsifiers, defoamers, fillers, etc. In European classifications, these substances are abbreviated “E”. It is necessary to understand that the composition of food (technological) additives can include not only synthetic and non-food substances, but also ordinary natural food substances, for example, vitamin E and ascorbic acid (as antioxidants), pectin and alginates (as gelling agents and fillers), natural flavors and food colors.

There are several approaches to the classification of dietary supplements.

Based on their sources, dietary supplements are divided into several groups, highlighting those created on the basis of:

ü proteins, amino acids and their complexes;

ü essential (irreplaceable by the body) lipids;

ü carbohydrates and sugars;

ü dietary fiber;

ü pure substances of macro- and micronutrients;

ü natural minerals and mumiyo;

ü food and medicinal plants, including pollen;

ü processed meat and dairy raw materials, by-products, arthropods, amphibians, beekeeping products;

ü seafood;

ü probiotic microorganisms;

ü unicellular algae;

ü yeast.

The Institute of Nutrition of the Russian Academy of Medical Sciences has developed a classification based on the effect on the body:

ü Nutraceuticals;

ü Antioxidants;

ü For weight control;

ü Stimulating the functional activity of individual organs and systems;

ü Promoting the healing of bone injuries;

ü Sedative effects;

ü Male (for the prevention of prostatitis, restoration of potency, etc.) and female (for the formation of lactation, during menopause, etc.);

ü Toning;

ü To maintain intestinal function, digestion, bile secretion;

ü General strengthening;

ü Eubiotics

Considering the possibility of using dietary supplements for medicinal purposes, modern classification involves dividing them into three main classes:

ü Nutraceuticals

ü Parapharmaceuticals

ü Eubiotics

Nutraceuticals are biologically active food additives used to correct the chemical composition of human food. These are additional sources of nutrients: protein, amino acids, fats, carbohydrates, vitamins, minerals, dietary fiber.

Nutraceuticals include natural food components, the physiological need and biological role of which have been established. The ultimate goal of their use is to improve human nutritional status and strengthen human health.

Functions of nutraceuticals:

ü elimination of deficiency of essential nutrients;

ü optimization of the nutrition of a specific healthy person depending on gender, age, genetically programmed characteristics, biorhythms, environmental conditions;

ü increase in nonspecific resistance of the body.

The ultimate goal of using nutraceuticals is to improve a person's nutritional status, promote health, and prevent a number of diseases.

Parapharmaceuticals are biologically active food additives used for disease prevention, auxiliary therapy and support within the physiological boundaries of the functional activity of organs and systems.

Functions of parapharmacists:

ü regulation within physiological boundaries of the functional activity of organs and systems;

ü adaptogenic effect;

ü regulation of nervous activity;

ü disease prevention;

ü auxiliary therapy.

Eubiotics (probiotics) are bacteriological dietary supplements that contain live microorganisms and (or) their metabolites that normalize the microflora of the digestive tract. Modern eubiotics often include a substrate that promotes the growth of friendly flora, but is not absorbed by the human body.

The main differences between dietary supplements and medications.

ü Dietary supplements specifically support the body within physiological limits, that is, they act as auxiliary substances in complex therapy;

ü medicines contain a therapeutic dose of the active substance, and dietary supplements contain a physiological dose; in this case, the daily dose of dietary supplements does not exceed a single therapeutic dose and no more than 60% of the therapeutic dose;

ü method of application, composition and release form - dietary supplements are taken only orally: in the form of capsules, tablets, syrups, less often - emulsions, suspensions.

ü Any person who has previously read the instructions and become familiar with the contraindications can use dietary supplements;

Table 1. Comparative characteristics effects of dietary supplements and pharmacological drugs

	Pharmacological drugs
Specificity of action
Regulation of a very wide range of biochemical reactions and physiological functions. A specific action is always accompanied by non-specific effects that are beneficial to health.	Strictly selective and highly specific action. Nonspecific effects most often manifest themselves as toxic or adverse reactions.
Physiological action
The therapeutic effect is realized through physiological mechanisms.	The therapeutic effect in most cases is realized through non-physiological and evolutionarily uncharacteristic mechanisms.
Toxicity and adverse reactions
For most dietary supplements there is no toxic dose. In other cases, toxic effects are predictable and easily preventable.	For many medications, the therapeutic corridor is very narrow. Toxic reactions and overdose occur frequently.
Interaction with other drugs
Interaction with other dietary supplements in most cases is characterized by synergy and contributes to maximum effectiveness.	Interactions with other pharmaceutical drugs are often characterized by antagonism, neutralization of the therapeutic effect, or aggravation of toxic reactions (so-called polypharmacy).
Speed of achieving effect
The effect is slow and short-lived.	The effect is quick but short-lived (often at the cost of toxic or adverse reactions).

1.2 Composition of dietary supplements

The list of possible components of dietary supplements is strictly regulated by regulatory documents.

In accordance with SanPiN 2.3.2.1078-01 in the Russian Federation, the following can be used for the production of dietary supplements for food:

Nutrients: proteins; fats, fat-like substances; fats of fish and marine animals; individual polyunsaturated fatty acids isolated from food sources; carbohydrates and products of their processing; starch and its hydrolysis products; inulin and other polyfructosans; glucose, fructose, lactose, lactulose, ribose, xylose, arabinose; vitamins, vitamin-like substances and coenzymes; minerals (macro- and microelements: calcium, phosphorus, magnesium, potassium, sodium, iron, iodine, zinc, boron, chromium, copper, sulfur, manganese, molybdenum, selenium, silicon, vanadium, fluorine , germanium, cobalt).

Minor food components.

Probiotics and prebiotics; various classes of oligo- and polysaccharides; biologically active substances - immune proteins and enzymes, lysozyme, lactoferrin, lactoperoxidase, bacteriocins of lactic acid microorganisms, with the exception of preparations from human tissues and fluids).

Plants (food and medicinal), products of the sea, rivers, lakes, reptiles, arthropods, mineral-organic or mineral natural substances (in dry, powdery, tablet, encapsulated form, in the form of aqueous, alcoholic, fatty dry and liquid extracts, infusions, syrups, concentrates, balms): mumiyo, spirulina, chlorella, inactivated yeast and their hydrolysates, zeolites, etc.

Bee products: royal jelly, propolis, wax, pollen, bee bread.

At the same time, the production of dietary supplements from the following components is prohibited:

Plants containing potent, narcotic or toxic substances.

Substances not characteristic of food, food and medicinal plants.

Non-natural synthetic substances - analogues of the active principles of medicinal plants (which are not essential nutritional factors).

Antibiotics.

Hormones.

Potentially hazardous animal tissues, their extracts and products.

Human tissues and organs.

Spore-bearing microorganisms; representatives of genera and species of microorganisms, among which opportunistic variants of microorganisms are common; live yeast.

Plants and products of their processing that are not subject to inclusion in the composition of one-component biologically active food additives.

Medicinal plants as components of dietary supplements.

For the production of dietary supplements, food and medicinal plants are used, which contain a rich complex of biologically active substances - such as bioflavonoids, vitamins, polysaccharides, amino acids, microelements, etc. Modern technologies and equipment make it possible not only to extract this entire complex as much as possible, but also to preserve its natural properties combination. This often leads to the fact that the bioavailability and effectiveness of each of the biologically active substances is significantly enhanced. For example, phenolic compounds are more active in combination with polysaccharides, vitamin C is more effective in combination with flavonoids (rutin).

The concentration of biologically active substances in plant extracts is such that it then allows the resulting food additives to be used in a relatively small quantities(doses) sufficient for both prevention and complex therapy of diseases.

The use of a large assortment of medicinal plants containing various natural substances makes it possible to create dietary supplements with wide possibilities for correcting various disorders in the body.

As noted above, the use of highly toxic natural remedies - poisonous and potent medicinal plants - as part of dietary supplements is unacceptable. Dietary supplements for food are not strictly dosed and controlled, they are recommended for people of any age and therefore cannot contain substances with possible toxic properties.

To obtain dietary supplements, official plants are used. They are relatively well studied in terms of chemical composition and pharmacological properties. In this case, a more in-depth study of these parameters is often carried out. This allows us to obtain new information and expand the scope of application of many medicinal plants.

For example, yarrow extract (Achillea millefolium) is known as a stomach remedy and is used as a medicinal product and dietary supplement - "Achillane" - for gastritis and gastric ulcers. However, it has been experimentally established that yarrow extract also relieves intestinal spasms and at the same time has a mild laxative effect throughout the intestines. In contrast to traditional laxatives (senna, buckthorn), which, irritating the intestines, release only its lower sections, causing colicky pain in the small intestine.

Horsetail (Equisetumarvense L), which is part of the Urolysin supplement, is a well-known medicinal plant recommended for diseases of the kidneys and urinary tract as an anti-inflammatory and diuretic. Experimental studies have established that horsetail extract does have a pronounced diuretic effect, but this effect is not accompanied by the removal of potassium and sodium salts from the body, which is its great advantage over synthetic diuretics - furosemide, hypothiazide, diacarb.

In addition, the raw materials for dietary supplements are medicinal plants used in folk medicine. Their composition is usually little studied, but they have proven themselves to be effective and harmless. Examples include marsh cinquefoil (Cómarumpalústre), Kuril tea (Potentillafructicosa), common oats (Avenasativa), tuberous sunflower (Helianthustuberosus L) and many others. At the same time, dietary supplements created on their basis must be subjected to experimental pharmacological studies for effectiveness and safety, and then to clinical trials.

Experimental research of medicinal plants used in folk treatment makes it possible to identify new, previously unknown pharmacological properties for them. Thus, the common cuff (Alchemillavulgaris L), which is part of the Venorm and Klimaton additives, is used in folk medicine as an anti-inflammatory agent. During the study, it was found that the cuff extract has a pronounced hemorheological effect, that is, it is able to reduce blood viscosity, which is very important for the treatment of patients who have suffered myocardial infarction, as well as those suffering from angina pectoris and other cardiovascular pathologies.

This kind of research can become the basis for the further use of folk remedies in official medical practice: the development of medicines based on the studied plants, the creation of appropriate regulatory documentation(VFS, FSP, etc.).

Chapter 2. Regulatory and legal issues of production and circulation of dietary supplements

1 Legal regulation of dietary supplements turnover

Legislation in the field of the use of dietary supplements regulates three main areas:

ü turnover of dietary supplements;

ü consumer protection;

ü protection of the manufacturer and distributor.

) Federal Law No. 52 of March 12, 1999 “On sanitary and epidemiological welfare” (as amended on 12/30/01, 01/10/06/30/03, 08/22/04);

) Federal Law No. 29 of January 2, 2000 “On the quality and safety of food products” (as amended on 12/30/01, 01/10/06/30/03, 08/22/04);

) Federal Law No. 2300-I of February 7, 1992 “On the Protection of Consumer Rights” (as amended from 06/02/93, 01/09/96, 12/17/99, 12/30/01, 08/22/04 .);

The very concept of dietary supplements was legally enshrined by order of the Ministry of Health of the Russian Federation No. 117 of April 15, 1997 “On the procedure for examination and hygienic certification of biologically active food additives.” According to this document, dietary supplements are defined as “concentrates of natural or natural-identical biologically active substances intended for direct intake or inclusion in food products in order to enrich the human diet with individual biologically active substances or their complexes.”

The order also stipulated the need for hygienic certification of dietary supplements by the United federal center certification on the basis of the Institute of Nutrition of the Russian Academy of Medical Sciences, determines the maximum doses of the active substance in the drug and gives the right to produce dietary supplements to both pharmaceutical companies and food industry enterprises. The same document prohibits the use of toxic and narcotic substances, as well as plants unknown to official medicine. In December 1997, by order of the Ministry of Health of the Russian Federation No. 349 “On the list of goods sold through pharmaceutical (pharmacy) organizations,” dietary supplements were admitted to pharmacy circulation.

The next major legal document regulating the circulation of dietary supplements was the guidelines MUK 2.3.2.721-98 “Determination of the safety and effectiveness of biologically active food additives”, which came into force on January 1, 1999, approved by the Chief Sanitary Doctor of Russia. The set of rules detailed the certification procedure for Russian and imported dietary supplements, set requirements for the quality of raw materials (in particular, since 1999, the use of transgenic materials, sheep and goat spleens, and cow skulls has been prohibited in the production of dietary supplements), determined the average daily consumption rates of micronutrients (deficient substances), which should guide nutraceutical manufacturers. It also stipulates the main difference between parapharmaceutical dietary supplements and drugs: the effect of dietary supplements is achieved only by stimulating the body’s own forces within the physiological norm.

The state established control over the production of dietary supplements on April 17, 2003, by approving SanPiN 2.3.2.1290-03 “Hygienic requirements for the organization of production and circulation of dietary supplements for food.” The same document prohibits the distribution of dietary supplements through network marketing, Internet and TV stores.

Mandatory state registration of dietary supplements has been introduced since 2004 by Federal Law of January 2, 2000 No. 29-FZ “On the quality and safety of food products.” The procedure for registration was stipulated by Decree of the Government of the Russian Federation of December 21, 2000 No. 988 “On state registration of new food products, materials and products.”

Registration includes several stages:

stage - primary (preliminary) examination of documents at the Federal State Institution IMC "Expertise" of Rospotrebnadzor and obtaining a referral for sanitary-chemical, sanitary-microbiological and other types of research at the State Research Institute of Nutrition of the Russian Academy of Medical Sciences.

stage - Conducting basic research and obtaining an Expert opinion from the State Research Institute of Nutrition of the Russian Academy of Medical Sciences. In accordance with the legislation of the Russian Federation, dietary supplements are not subject to mandatory clinical trials. This explains their wide distribution on the market. A manufacturer or developer of dietary supplements who wants to highlight any quality or property of dietary supplements can conduct clinical trials to confirm these properties and declare them in a Voluntary Certification document. The order of their implementation is determined by the “Methodological instructions MUK 2.3.2.721-98 2.3.2”.

stage - Obtaining a Certificate of State Registration.

Dietary additives registered on the territory of the Russian Federation are included in the “Federal Register of Dietary Supplements for Food” (maintained since 2000).

The main document certifying the quality of dietary supplements in Russia is the “declaration of conformity,” confirmation of the quality of dietary supplements directly by the manufacturer. Confirmation of the quality of dietary supplements by the Declaration of Conformity came into force on February 15, 2010 in accordance with Decree of the Government of the Russian Federation No. 982 of December 1, 2009.

2.2 Production of dietary supplements

The production of biologically active food additives can be carried out both in enterprises Food Industry, and at enterprises of the pharmaceutical and biotechnological industry.

The most significant Russian manufacturers Dietary supplements are:

"Evalar"

Russian pharmaceutical company JSC "Evalar", founded in 1991, specializes in the production of medicines from natural ingredients and dietary supplements, the range includes more than 120 items. Brand bestsellers: “Blueberry-Forte”, “Atheroklefit”, “Ovesol”, “Gepatrin”, calorie blocker “Turboslim”. Implements the full production cycle: from growing raw materials to sales finished products, including through its own pharmacy network. In 2008, Evalar CJSC, with a share of 20.85%, topped the list of leaders in the pharmacy segment of the dietary supplement market (according to the Pharmexpert Marketing Research Center).

OJSC "Diode Ecological Equipment and Ecofood Plant" (Moscow) sells dietary supplements, medicinal cosmetics, and household medical devices. Among the dietary supplements from this manufacturer, the most famous are “Oculist”, “Iodine-Active”, “Calcium-Active”, “Selenium-Active”, “Longevity”, “Soulful Tea”. According to the pharmaceutical publication "Moscow Pharmacies", the drug for normalizing peripheral blood circulation "Capilar" in 2015 became the all-Russian sales leader among dietary supplements sold through pharmacy chains. In 2016, the company’s market share was 7.9% in monetary terms. OJSC Diod owns the World of Ecology chain of stores in Moscow and the Moscow region.

"Akvion"

The pharmaceutical company Akvion CJSC, which began operating in 1991, produces substances for the cosmetics and food industries, and also produces dietary supplements. Akvion maintains its leading position in the dietary supplement market through sales of the Alphabet series of vitamin and mineral complexes, which embody the idea of taking components separately, taking into account the compatibility of the components. The company's leading developments include the immune-strengthening beta-carotene preparation Vetoron and the dietary supplement based on coenzyme Q10 Kudesan.

Medicines trademark NaturProdukt appeared in Russia in 1994. Currently, the company supplies 34 product lines, including over 150 product items. The production specializes in over-the-counter drugs, dietary supplements and generic drugs. The best sellers among NaturProdukt dietary supplements were the fortified candies “Naturino” and “Naturetto” and the general strengthening tablets “Terra-Plant”. The NaturProdukt holding has a branded network of pharmacies. Its production team is based overseas in Europe.

Foreign suppliers of dietary supplements:

The Danish-Swedish company FerrosanAG was founded in 1920 in Denmark. The Russian representative office of Ferrosan International A/S opened in 1996. In Russia it is known primarily as an importer of the vitamin and mineral complex Multi-tabs, which at the end of 2009 was one of the hundred best-selling dietary supplements in Russia. The DSMGroup rating also includes the following FerrosanAG brands: the intestinal microflora normalizing agent “Bifiform”, the anti-aging product Imedeen, the drug for the prevention of vision disorders “Strix”.

The Canadian pharmacological company PharmaMed has been present on the Russian market since 1995. Since 2009, for the first time it has been among the top five leading brands among Russian sellers of dietary supplements. PharmaMed promotes five main brands: Lady’sformula, Man’sformula, Kid’sformula, Lifeformula and Dietformula. The most popular among Russians, however, is the drug for restoring reproductive function in men, SpermActin.

The company debuted in 1874 in Norway; in Russia, the representative office of the Swiss Nycomed was registered in 1993. In the global pharmaceutical market, the company holds 28th place and 15th position in terms of sales of over-the-counter drugs. From the dietary supplement range of this manufacturer, Russian consumers highlight the drug “Gerimaks” and vitamin complexes “Sana-sol”. Currently, Nycomed sells its products in more than 120 cities and regions of Russia and the CIS.

Forms of release of dietary supplements:

According to the Appendix to the above-mentioned Order of the Ministry of Health No. 117, “Biologically active food additives are produced in the form of extracts, infusions, balms, isolates, powders, dry and liquid concentrates, syrups, tablets, capsules and other forms.”

Traditionally, the vast majority of dietary supplements are produced in the form of tablets, gelatin capsules containing dosed dry powders, as well as teas. Significantly fewer dietary supplements are presented in liquid forms, although the bioavailability of such products is approximately 4 times higher than that of dry ones. Thus, in the USA, dietary supplements of the "PocketShot" system, which have a gel consistency and are packaged in special plastic bottles, are gaining great popularity. Among the Russian additives in the form of liquids, such products as Adaptovit, Bioselen, Epam, and a number of balms (Ussuri Balsam, Ussuri Surprise, Gerbamarin, etc.) are produced.

In foreign countries, food products with dietary supplements are popular - the so-called “conventional food”, “functional food”. In Russia there are also more and more similar products.

The main factors influencing the quality of dietary supplements include:

ü balanced recipe;

ü composition and parameters of raw materials and packaging;

ü production processes, technological equipment and personnel qualifications;

ü organization of production control and testing;

ü conditions of storage, transportation and sale.

Let's take a closer look at these factors.

Dietary supplement recipe

To create effective dietary supplements, qualified, long-term and detailed studies of nutritional value, pharmacological activity, physical and chemical properties of products, a study of the compatibility of the components included in their composition, and much more are required, which in total will allow positioning the product as objectively necessary for a certain group of consumers. Not every dietary supplement developer can afford these expensive studies. Usually the matter is limited to the standard procedure of sanitary and epidemiological examination, which includes confirmation of the safety of the product (microbiological purity, content of pesticides, toxic elements, radionuclides) and the presence of biologically active substances. However, the data from these studies cannot be fully comprehensive.

Standardization of dietary supplements

The purpose of standardizing dietary supplements and presenting test methods in technical specifications (hereinafter referred to as TS) is to guarantee stable product quality during mass production. Most registered dietary supplements in the section of the technical specifications “Methods for product quality control” provide links to methodological guidelines, GOSTs, pharmacopoeial monographs or excerpts from them. As a rule, the methods specified in the technical specifications are not suitable for testing declared products, since they have not developed sample preparation methods , the influence of other components on testing is not taken into account, which leads not only to significant errors in the qualitative and quantitative determination of biologically active substances, but also to the impossibility of reproducing the methods and, therefore, obtaining a reliable result. It is quite obvious that each type of product requires laboratory-tested methods for the quantitative and qualitative determination of biologically active substances, as well as physical and chemical indicators. The development and statistical validation of methods requires dozens and sometimes hundreds of tests.

Quality of raw materials

Raw materials are one of the fundamental factors shaping the quality of the product. In the production of dietary supplements, the quality of the finished product largely depends on the composition of the raw material, compliance with the norms and rules of its pre-processing.

The raw materials (usually plant-based) used in the production of dietary supplements are multicomponent mixtures of complex composition. Standardization and quality assessment of this type of raw material is a very difficult task, including for the pharmaceutical industry, both in Russia and abroad. Despite certain achievements in pharmacognosy, in practice the main quality criterion is the reliability of the supplier and the availability of accompanying documentation for the batch of raw materials. The problem of preliminary assessment of the quality of raw materials in the production of dietary supplements is no more acute than in the pharmaceutical and food industries,

Formally, all raw materials purchased for the production of dietary supplements must have certificates, test reports or other documents confirming their quality. But practice shows that if storage and transportation conditions are violated, the quality of raw materials may deteriorate, which is not always reflected in its appearance. Consequently, confirmation of the suitability of the starting raw material for production requires testing for compliance with regulatory documentation (the so-called incoming control), which will guarantee the quality of the finished dietary supplement product (excluding technological errors).

Packaging, labeling, storage of dietary supplements.

Packaging of dietary supplements must ensure safety and ensure the quality of dietary supplements at all stages of circulation.

When packaging dietary supplements, materials must be used that are approved for use in the prescribed manner for contact with food or medicines.

Requirements for information on the dietary supplement label are established in accordance with current legislative and regulatory documents governing the inclusion of consumer information on the label.

Information about dietary supplements should contain:

names of dietary supplements, and in particular:

manufacturer's trademark (if available);

designations of normative or technical documentation, the mandatory requirements of which must be met by dietary supplements (for dietary supplements of domestic production and CIS countries);

composition of dietary supplements, indicating the ingredient composition in order corresponding to their decrease in weight or percentage terms;

information about the main consumer properties of dietary supplements;

information about the weight or volume of dietary supplements per unit consumer packaging and weight or volume of a product unit;

information about contraindications for use in certain types of diseases;

an indication that the dietary supplement is not a medicine;

date of manufacture, guarantee period expiration date or deadline for the sale of products;

storage conditions;

information on state registration of dietary supplements indicating the number and date;

location, name of the manufacturer (seller) and location and telephone number of the organization authorized by the manufacturer (seller) to accept claims from consumers.

The use of the term “environmentally friendly product” in the name and when applying information on the label of dietary supplements, as well as the use of other terms that do not have legislative and scientific justification, not allowed.

Requirements for storing dietary supplements.

There are strict requirements for food storage, which are reflected in the list of regulatory documents for food storage conditions - Federal Law No. 29.

Food products must be stored in premises that must meet all the requirements of sanitary, hygienic and epidemic standards (in accordance with current legislation). Storage at necessary conditions ensures safety, quality and safety when using food supplements.

Organizations involved in the storage of dietary supplements must be equipped, depending on the assortment:

racks, pallets, stock racks, cabinets for storing dietary supplements;

refrigeration chambers (cabinets) for storing thermolabile dietary supplements;

means of mechanization for loading and unloading operations (if necessary);

instruments for recording air parameters (thermometers, psychrometers, hygrometers).

Thermometers, hygrometers or psychrometers are placed away from heating devices, at a height of 1.5 - 1.7 m from the floor and at a distance of at least 3 m from the door. The readings of these devices are recorded daily in a special journal. Control devices must undergo metrological verification within the established time limits.

Each item and each batch (series) of dietary supplements is stored on separate pallets. A rack card indicating the name of the dietary supplement, batch (series), expiration date, and number of storage units is attached to the shelves, cabinets and shelves.

Dietary supplements should be stored taking into account their physical and chemical properties, under the conditions specified by the manufacturer of the dietary supplement, observing temperature, humidity and light conditions.

In the description of dietary supplements, the manufacturer indicates, among other things, storage conditions (temperature, humidity, lighting).

Thus, probiotic dietary supplements (eubiotics) require a constant temperature during storage, usually up to 20 degrees. This is reflected on the dietary supplement label. In addition, probiotic dietary supplements must undergo visual inspection once a month. Dietary supplements, which are herbal mixtures of dried plants, are stored in a dry, cool place, in airtight packaging. Similar requirements apply to dietary supplements containing essential oils. The most stringent requirements apply to the storage of medicinal dietary supplements. Thus, tableted dietary supplements and dietary supplements in the form of tinctures and syrups are stored in a dry, cool place, protected from light.

If storage and transportation requirements are violated, dietary supplements may change their properties and qualities. In such cases, legal entities and individual entrepreneurs must inform owners and consumers of dietary supplements. These dietary supplements are withdrawn from circulation and sent for examination.

Chapter 3. Practical part

1 Analysis of the range of dietary supplements in a pharmacy organization

The main stage of formation Russian market Dietary supplements for food should be considered 1998 - 2001, since it was during this period that the main regulatory documents regulating the conduct of clinical trials, registration, quality and safety control, and circulation of dietary supplements were developed and approved.

The modern Russian dietary supplement market demonstrates high growth rates. Over the past seven years, the volume of products in legal circulation has more than quadrupled, and the increase in demand for dietary supplements is 10-12% annually. The sales segment of dietary supplements is growing twice as fast as the group of medicines. Such rapid development is greatly facilitated by the simplified system of registration and certification of dietary supplements. Many pharmaceutical companies, even having sufficient resources for the production of medicines, prefer to register their developments as dietary supplements.

The following groups of dietary supplements are most in demand among the population: agents affecting the digestive organs (market share - 25.9%), regulating tissue metabolic processes (21.5%), supporting the function of the musculoskeletal system (9.5%), normalizing vision (6.5%), regulators of hormonal metabolism (6%), sources of minerals (4.5%), antioxidants (3.9%), agents for the prevention of diseases of the cardiovascular system (3.6%), influencing on the nervous system (3.2%). 39% of buyers preferred dietary supplements costing $3-7 per package.

The motivation for purchasing among 38% of consumers is ailments, 34% want to strengthen the immune system with the help of dietary supplements, 28% are interested in prevention.

Figure 1. Motivation for purchasing dietary supplements

Figure 2. Selecting a range of dietary supplements

When choosing from a range of dietary supplements, 44% of consumers are guided by price, 22% buy supplements on the recommendation of a doctor, and 13% - by a pharmacist, 21% - by other things.

Consumer perception of dietary supplements:

Ø Not drugs (44%), but almost drugs (25%).

Ø Produced by non-pharmaceutical companies (58%).

Ø Consist only of natural ingredients (56%).

Ø Much safer than drugs (64%).

Ø Suitable for the treatment of non-severe diseases (66%).

Ø Dietary supplements do not treat, but are used only for prevention/health improvement (75%).

Ø Consumers do not have a clear idea of the cost level of dietary supplements.

Ø Consumers do not know that dietary supplements are a supplement to the diet.

Ø Dietary supplements should be in the diet of every person (63%).

3.2 Strategy for developing an assortment of dietary supplements in a pharmacy organization

Determining the optimal assortment, including dietary supplements, is one of the most pressing tasks facing the manager of both a single pharmacy and a pharmacy chain. The product range for a pharmacy organization is of great importance, since it determines the degree to which consumer demand is met, and therefore affects the overall quality of service. In addition, a rationally formed assortment accelerates inventory turnover (therefore, contributes to the growth of trade turnover), which directly affects the efficiency of the enterprise. According to the literature, only by optimizing the assortment can the turnover of a pharmacy organization be increased by 10-15%.

Marketing strategy is the basis for the activities of any enterprise in conditions of developed market demand.

As you know, there are several types of business strategies:

Undifferentiated (mass) marketing;

Differentiated (customer-oriented) marketing.

The formation of the assortment can be based on defect analysis, own sales and retail audit. Forming an assortment based on defects is the most common method. However, it is not without its drawbacks, since it does not reflect stable demand and provides distorted data due to an insufficiently effective system for recording defects.

Forming an assortment by analyzing one’s own sales is effective in determining optimal stocks, but such analysis does not reflect the development trends of the regional market; it is characterized by distortion of data due to an initially incorrectly formed assortment, defects and pricing policy.

Retail audit data allows you to:

Assess the assortment structure of the regional dietary supplement market;

Control the assortment within the competitive group;

Monitor price trends.

When using retail audit data, it should be borne in mind that this is an average picture of the market, so it is necessary to take into account specific factors, such as pharmacy specialization, service format, location.

In conditions modern market The main criteria for forming the assortment of a pharmacy organization are supply and demand. Therefore, when assortment planning of dietary supplements, it is necessary to determine their optimal relationship with demand, analyze the supply, paying special attention to the quality of dietary supplements, its price, delivery conditions and advertising activity of the manufacturer.

According to the literature, it has been revealed that most pharmacy enterprises are currently practicing a mass marketing strategy. Choosing such a strategy means that the emphasis is not on the differences in the needs of individual consumer groups, but on what these needs have in common. As a result of following this strategy, the product range includes dietary supplements designed to satisfy the needs of the widest market segment. Most often, with this approach, the head of a pharmacy enterprise is focused on supply, which means that the assortment is “formed” for him by distributors and manufacturers. If such a strategy is also pursued by other pharmacy organizations (especially “neighboring” and competitors), there is an increase in competition, which means a reduction in prices and profitability of the enterprise.

The growing number of players and increased competition between them lead to an aggressive struggle for buyers. The buyer, in turn, tightens the requirements for the product and level of service. Competition The winner is the one who is more able to adapt the quality of his product (and this is the quality of both goods and service) to the requirements of the buyer. The era of customer-oriented marketing is coming in the market, when it is necessary to identify the needs and preferences of your client and, based on this, select and offer him a product.

Differentiated target marketing involves:

Identification of a key consumer group;

Opportunities for varying selling prices.

With a differentiated marketing strategy, a pharmacy develops its own assortment for each group of customers. To do this, it is necessary to understand what the differences in the needs of individual consumer groups are and how this is explained. Thanks to this strategy, it is possible to achieve deeper penetration into the target segment of the dietary supplement market. The differentiated marketing strategy leads to an increase in turnover for the sale of dietary supplements due to the fact that customers are offered many individual types of dietary supplements aimed at a specific category of clients.

To identify customer categories, the average purchase size and traffic indicators are determined. In addition to such marketing analysis, customer information is collected based on customer surveys.

The initial collection of information can be carried out at the entrance to the pharmacy, when the visitor is asked the question: “What do you intend to buy in our pharmacy?” The response received is recorded in a special journal according to the proposed form (Table 3).

Table 3. Journal form for determining the range of purchased dietary supplements

After completing this stage, the next stage begins - processing and analysis of the results obtained. Based on the results of the survey, it is determined which dietary supplements were planned by the buyer and which were ultimately purchased, in addition to those named at the entrance to the sales floor.

For analysis, it is advisable to use the ABC method, which is used to assess the attractiveness of various products. The essence of the method is that all products are divided into three groups (A, B and C) depending on their degree of importance for consumers and on the attitude of consumers towards them, taking into account their marketing characteristics.

According to the analysis of five hundred names of dietary supplements sold through pharmacies and ranking them by the number of mentions depending on the type of disease or symptom, it was found that dietary supplements occupying the first three places in the ranking were classified as group A, occupying 4-, 5- and 6 1st place in the ranking - to group B and those occupying 7th, 8th and 9th place - to group C (Table 35).

The analysis showed that group A includes such dietary supplements as iodine-active, capillary, arthrovit, blueberry forte, brewer's yeast, milk thistle meal, weight loss teas, tablets, ointments, herbal teas from Sofya, Leovit, Evalar ", which are in greatest demand and are available in almost all pharmacy organizations.

Group B includes such dietary supplements as longevity, selenium-active, calcium-active, fish oil, mumiyo and others, which are also in great demand.

Research of dietary supplements by group showed that dietary supplements of group A include dietary supplements that are purchased most often and as planned. They are "goods" everyday needs", "products of the main consumer basket", "habitual purchases" and are characterized by minimal buyer involvement.

Table 4. Distribution of dietary supplements by groups A, B and C

Type of disease or symptom	Number of mentions	Group of dietary supplements
To boost immunity
For weight loss
Cardiovascular diseases
For figure correction
To improve vision
Supports musculoskeletal function
For alcohol addiction
To quit smoking
Supports Digestive Function
To relieve stress

Group B dietary supplements include pre-selected dietary supplements, which are purchased relatively rarely.

Group C dietary supplements include dietary supplements of impulsive demand, which the consumer does not know about or does not think about purchasing under normal conditions. The buyer does not have a clear idea about them or an expressed need to purchase them. In this case, the pharmaceutical professional must make special efforts to enhance their sales. Table 36 presents the characteristics of dietary supplements by group in accordance with consumer behavior.

The results of the analysis showed that dietary supplements of group A are less attractive in terms of key financial performance indicators than dietary supplements of other groups. For example, with a share in turnover of about 50%, they form only 10% of the profit of a pharmacy enterprise, and high turnover and large physical volumes require transportation and storage costs (Table 38). Their advantages are that they provide the main flow of buyers.

Group B dietary supplements occupy an average position in all characteristics. Their purpose in merchandising is “self-selling”. With a turnover share of about 40%, they provide 40% of all profits. For their placement, neutral or less attractive areas are used than for other groups of dietary supplements.

Group C dietary supplements differ from other groups of dietary supplements in the variety of types and large number of items, which creates difficulties in forming an assortment. The advantage of this group is to profit from small sales volumes: with a share of turnover of about 10%, they bring in more than 30% of all profits. In addition, group C dietary supplements support secondary customer flows and contribute to the formation of a sustainable source of profit. However, to sell them you need to make more effort than when selling goods of other groups and require placement in “hot zones”.

Conclusion

Dietary supplements are a very important and useful component of a healthy lifestyle, which, if used correctly, allows you to avoid many health problems or reduce their severity. A significant role in this is played by the widespread use of medicinal plants as components of dietary supplements.

Plant raw materials are not only a source of micronutrients, but also often contain a whole complex of pharmacologically active substances. Their ratio and dosage determine a mild, long-lasting effect and the absence of side effects with long-term use.

The main problems of using medicinal plants in the production of dietary supplements:

ü Development of a BAS formulation taking into account the interaction of components

ü Ensuring proper quality of raw materials

ü Standardization of finished products according to the content of active ingredients

It is important to remember that dietary supplements are not a medicine. They do not have a therapeutic effect on the body. Their main role is to replenish the lack of nutrients and micronutrients in the body.

The main problem of dietary supplements today is the issue of ensuring their proper quality. The main directions of its solution are strengthening control at all stages of production and sales. It is also very important to conduct research and clinical trials of dietary supplements. Another pressing problem is training medical workers in the field of nutrition. It seems to me that solving these problematic issues will make the use of dietary supplements safe and effective.

conclusions

The presented data and research results clearly indicate that the growing deficiency of micronutrients is the most common and dangerous nutritional disorder, causing serious damage to the health of the Russian population. Deficiency of vitamins, macro- and microelements, characteristic of a large number of healthy people, is aggravated by any diseases, especially diseases of the gastrointestinal tract, liver and kidneys, in which there is a violation of the absorption and utilization of micronutrients. Drug therapy and surgical interventions further contribute to the worsening of micronutrient deficiencies.

Proper use of dietary supplements allows you to both replenish the balance of missing natural substances in the body and prevent various diseases, and at a certain age, reduce the level of morbidity and even mortality.

Each body is individual, and promoting dietary supplements as a panacea for the entire population is very dangerous. And harmful.

Bibliography

1. Pilat T. L., Ivanov A. A. Biological additives to food. - M, 2012. - 710 p.

2. Gichev Yu. Yu., Gichev Yu. P. Guide to micronutrientology. The role and significance of biologically active food additives. - M.: “Triad-X”, 2009. - 264 p.

3. Trukhan D. Journey through the labyrinth of dietary supplements // Moscow pharmacies. - No. 9 (153). - 2009.

4. Dietary supplements are good! // Around the world,. - No. 2 (2749). - 2010

5. Knyazhev V. A. Sukhanov B. P., Tutelyan V. A. Proper nutrition. Supplements you need. - M.: Geotar medicine, 2008. - 208 p.

6. SPS Garant Plus

7. Shabrov A.V., Dadali V.A., Makarov V.G. Biochemical basis of the action of food microcomponents. - M., 2008. - 166 p.

8. Gorshunova L.N., Tyurenkov I.N. Practice of managing the assortment of a pharmacy enterprise. // Economic Bulletin of Pharmacy. - 2009 - N 10.

9. Kobzar L.V. Assortment and assortment policy pharmacy establishment. // New pharmacy. - 2008 - N 3

10. Tarasevich V.N., Novikova N.V., Soloninina A.V., Odegova T.F. Legal basis for the formation of an assortment of goods in pharmacy organizations // Contemporary issues science and education. - 2013. - No. 3

13. Gruzdeva A. // Classifications of dietary supplements: Seminar proceedings // World FM. - 2007, p. 138

14. Marketing analysis in developing an assortment for manufacturers of drugs and dietary supplements // Consulting and training A.S. Slavich-Pristupy on pharmaceutical business and dietary supplements, 2011.

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Appendix 2

Appendix 3 List of main regulatory documents regulating the circulation of dietary supplements in Russia

1. Federal Law of March 30, 1999 No. 52-FZ “On the sanitary and epidemiological welfare of the population” (as amended on December 30, 2001, January 10, June 30, 2003, August 22, 2004).

Federal Law of January 2, 2000 No. 29-FZ “On the quality and safety of food products” (as amended on December 30, 2001, January 10, June 30, 2003, August 22, 2004).

Vitamin-mineral complexes as sources of natural substances necessary for the body. Dietary supplements, their composition, functions and classification. Development of recommendations for optimizing the range of nutritional supplements in a pharmacy organization.

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INTRODUCTION

1.3 Regulatory basis for the presence of dietary supplements on the pharmaceutical market of the Russian Federation

CHAPTER 2. GENERAL CHARACTERISTICS OF THE RESEARCH BASE

CHAPTER 3. RESULTS OF OWN RESEARCH

CONCLUSION ON THE RESEARCH

LIST OF REFERENCES USED

INTRODUCTION

Relevance of the topic. In system market relations The sustainable functioning of pharmacy organizations and the ability of them to fulfill their social mission primarily depend on the product range offered for sale to the public in retail trade, which must meet the expectations and ideas of the target audience and act as a key factor in the competitiveness of an economic entity.

However, maintaining and strengthening positions in the market in conditions of its saturation, constant changes in the assortment, growing customer needs and increased competition both between retailers trading enterprises, selling certain groups of parapharmaceutical products, and pharmacy organizations force the latter to look for new opportunities for economic development in a competitive environment. One of these areas is the use of marketing in the process of updating, expanding and diversifying the product range. The use of marketing tools in managing the range of products allows pharmacy organizations, taking into account the needs and preferences of consumers, to create sustainable competitive advantages.

Of particular interest in this case is the management of the assortment of dietary supplements - currently the growth rate of sales of dietary supplements is increasing, however, the issues of managing their assortment are not always sufficiently developed and customer-oriented in pharmacy organizations.

Purpose of the study: analysis of the assortment of dietary supplements in the pharmacy organization “Melody of Health” (Voronezh).

Research objectives:

1. Conduct a literature review related to the research questions.

2. Present the material and research methods.

3. Process and present the results of your own research.

4. Present a conclusion on the research conducted.

5. Summarize the results of the work and develop recommendations for the study.

CHAPTER 1. ROLE AND IMPORTANCE OF BIOLOGICALLY ACTIVE FOOD ADDITIVES

1.1 Vitamin-mineral complexes as sources of natural substances necessary for the body

Comprehensive nutrition includes a balanced diet of proteins, proteins, fats, minerals and other beneficial substances necessary for our body. In search of these “ingredients” for healthy, and therefore happy life, first of all we turn to food products. In conditions of deteriorating environmental conditions, especially in large cities, food products are losing their beneficial features and cannot fully provide the entire set of necessary substances. According to official statistics, 64.1% of citizens of our country do not comply with their diet.

It is vitamin-mineral complexes that are the only source of natural substances necessary for the body, many of which the human body is not able to synthesize on its own. The key issue here is the individual’s understanding of the value of his own health as a vital capital and the need for personal responsibility for it.

Dietary supplements (BAA), which are controversial in Russia, can play a significant role in helping the population. It is clear that high-quality products of this kind can significantly improve human health and affect labor productivity.

1.2 Dietary supplements their composition, functions and classifications

Biologically active food additives (BAA) are compositions of biologically active substances intended for direct intake with food or inclusion in food products.

For man in ancient times, medicines were those substances and products that he ate. That is, roots, fruits, bark, leaves and stems of plants, body parts and organs of various animals (including those that, from a modern point of view, are generally considered inedible), soil and minerals.

Information about the therapeutic and health-improving effects of nutrients was preserved in ancient Eastern medicine (ancient Chinese, ancient Indian, Tibetan), which has survived to this day. The formulations of therapeutic and prophylactic drugs of that time had a very complex, multi-component composition and were of natural origin. One of the consequences of this integrative process was the widespread use of biologically active food additives, which are, as a rule, derivatives modern technologies.

Let us turn to what dietary supplements are in terms of their composition, functions and classification.

According to the Ministry of Health, food additives containing biologically active ingredients (BAI), separated in 1994 from medicines into a separate group, are concentrates of biologically active substances. They are intended for direct intake or introduction into food products in order to enrich the human diet with individual biologically active substances or their complexes.

Classification of dietary supplements:

All dietary supplements existing today are divided into three groups: nutraceuticals, parapharmaceuticals and eubiotics.

Nutraceuticals are biologically active food additives used to correct its chemical composition.

Nutraceuticals include vitamins, vitamin-like substances, minerals, amino acids or peptide complexes, dietary fiber, etc.

Functions of nutraceuticals:

1) quickly and easily cover the lack of vital nutrients;

2) make it possible to adjust the individual diet for a specific person with no illnesses, taking into account factors such as his work, gender, age, genetic factors, biorhythms, physiological characteristics (pregnancy or lactation), environmental conditions, etc. ;

3) increase the body’s resistance in humans by enhancing the enzymatic protection of cells to influence unfavorable factors environment, especially in environmentally disadvantaged areas;

4) purposefully change the metabolism in the body in order to maximally satisfy the nutritional needs of a person with diseases;

5) have immunomodulatory properties, enhance the removal of toxic and foreign substances from the body (radionuclides, various heavy metals).

Nutraceuticals are divided into the following groups of dietary supplements:

1. Herbal preparations (diet modifiers).

This group mainly consists of drugs for weight loss. Vitamins, amino acids, and various microelements can be found in their composition. That is, in other words, their composition is not much different from multivitamins and immune support complexes. They assume the effect of losing weight is due to a general improvement in health.

As an example, let’s take the Mega Slim phytoactive complex, which is designed specifically for use in nutritional systems for weight loss (diets). According to the manufacturer - Russian company"LEOVIT nutrio" - it combines the latest scientific developments in the field of nutrition and many years of medical experience. When creating it, modern concepts about safe and effective weight loss were used.

Figure 2 - Phytocomplex "Mega Slim"

Contains:

Vitamin premix (vitamins: C, PP, E, B5, B6, B2, B1, B9, H, B12)

L-carnitine, cinnamon, bromelain, guarana extract, zinc sulfate, corn silk extract, sodium selenite, magnesium sulfate, chromium picolinate.

Excipients: starch, talc, aerosil, calcium stearate

Shelf life: 2 years

Storage conditions: in a dry place, protected from light, at room temperature.

Before use, you should consult your doctor.

Action:

1) Body weight control. An increase or decrease in body weight is primarily associated with individual metabolic characteristics. Only by reducing fat mass, regulating carbohydrate metabolism and increasing protein absorption can results be achieved. Corn silk regulates metabolism, having a diuretic and choleretic effect, regulates appetite; Cinnamon increases the effectiveness of fat-burning components; Bromelain helps the breakdown of protein foods and their absorption by the body; B vitamins are involved in the processes of fat, protein and carbohydrate metabolism.

2) “Fat burning” effect

The components of "MegaSlim" are known for their lipotropic effect - the ability to mobilize fat from fat depots and accelerate its utilization. L-carnitine - key factor accelerating fat burning. Helps reduce the accumulation of fat in tissues and reduce body weight by reducing the proportion of fat, converting it into energy. A deficiency of L-carnitine in the diet leads to impaired fat metabolism; Zinc has a lipotropic effect, reducing fat content in the liver, and is necessary for the synthesis of insulin; Vitamin E is involved in the processes of breakdown and synthesis of fat; Vitamin PP takes part in energy metabolism.

2. Minerals (micro- and macroelements).

2.1 Macroelements (calcium, phosphorus, sulfur, potassium, sodium, magnesium).

Let's take Magne B6 FORTE as an example. This drug should be used if you have a magnesium deficiency. It is not recommended to use it if you have kidney disease, or if you have allergies.

Figure 3 - “Magne B6 FORTE”

2.2 Microelements (zinc, manganese, iron, chromium, selenium, copper, iodine, fluorine, cobalt).

As an example, let’s take the drug Iodine-Active®.

Figure 4 - Iodine-Active®

Iodine in Iodine-Active® is actively absorbed in case of iodine deficiency, and in case of excess, it is excreted from the body without entering the thyroid gland. This occurs due to the fact that iodine is cleaved from milk protein under the action of liver enzymes, which are produced when there is a lack of iodine. When there is enough iodine in the body, enzymes are not produced and Iodine-Active® is excreted naturally, without being absorbed into the blood.

Iodine is part of the thyroid hormones involved in the regulation of metabolism (including proteins, fats and carbohydrates), the functioning of the nervous and cardiovascular systems, reproductive and mammary glands, affecting the growth and development of the child.

Contraindications: Individual intolerance to dietary supplement components.

3. Sources of minerals.

One of the most famous examples of this category is “Hematogen” (for example, the manufacturer is a republican unitary enterprise"Exon", Republic of Belarus). Group: Dietary supplements - sources of minerals Subgroup: Dietary supplements containing iron Recommended as: an additional source of iron.

5. Sources of vitamins.

One of the most famous examples of this category is VITAMIN C ascorbic acid. Manufacturer HEMOFARM A.D. Composition: ascorbic acid and excipients, depending on the form of release.

6. Multivitamin preparations (complex).

For example, Additiva Multivitamins. Ingredients: 1 soluble tablet for the preparation of an effervescent drink with tropical fruit flavor contains vitamin B1 3.75 mg, vitamin B2 7 mg, vitamin B6 4.25 mg, vitamin B12 12.5 mcg, vitamin C 187.5 mg, vitamin E 30 mg, biotin 12.5 mcg, vitamin PP 37.5 mg, calcium D-pantothenate 25 mg, folic acid 0.5 mg; in tubes of 10 and 20 pcs., in a box 1 tube. Pharmacological action - multivitamin. Stimulates metabolic processes in the body.

8. Monovitamin preparations.

For example, Vitamin E from Zentiva / Slovakofarma, Slovakia. Composition: tocopherol acetate, depending on the dosage of the drug and excipients.

Figure 5 - Vitamin E from Zentiva / Slovakofarma

Sources of polyunsaturated fatty acids (PUFAs).

Example: Omeganol. It is a concentrated source of a number of substances that prevent the development of atherosclerosis: omega-3 and omega-6 polyunsaturated fatty acids, allicin and carotenoids of red palm oil.

Sources of ballast substances (dietary fiber).

An example would be bran. Dietary fiber contained in LITO bran perfectly stabilizes metabolism, removes radionuclides from the body, is a biosorbent of toxins, normalizes the function of the gastrointestinal tract, and ensures more complete absorption of nutrients. The intestinal microflora is improved under the influence of dietary fiber, creating favorable conditions for the development of beneficial bifidobacteria.

Each of the additives: fruits, vegetables or herbs, has different properties. Thus, “LITO” bran with seaweed is an invaluable source of iodine for humans, milk thistle in combination with bran provides liver protection, and the product with carrots is recommended for the prevention of colds.

Parapharmaceuticals are a class of dietary supplements that are similar in appearance and action to medications (tablets, capsules, tinctures, etc.). These can be preparations based on medicinal and food plants, bee products, and seafood. Parapharmaceuticals have general health-improving and restorative properties and can be used for prevention purposes and in the complex treatment of diseases. They usually contain natural biologically active substances of mineral or plant origin.

Parapharmaceuticals include:

Organic and mineral substrates - mumiyo (mountain resin).

2. Waste products of bees and animals: plant and animal poisons, honey, bile, propolis (a resinous substance produced by bees to seal cracks in the hive), antlers (growing deer antlers).

Herbal teas and herbal infusions.

Plant extracts with a high content of physiologically active substances: eleutherococcus, ginseng, lemongrass, golden root - radiola, seaweed.

The main goal of parapharmaceuticals is to activate and stimulate the work of individual organs and systems.

Classification of parapharmaceuticals:

1. Immunomodulators.

For example, Immunal. Pharmachologic effect. Immunal is a stimulant of nonspecific immunity. The juice of Echinacea purpurea, which is part of Immunal, contains active substances of a polysaccharide nature that stimulate bone marrow hematopoiesis, as a result of which the number of granulocytes increases by 34 - 89%, and also increases the activity of phagocytes and liver RES cells. Immunal has an antiviral effect (influenza and herpes viruses).

2. Adaptogens (increase the body’s resistance to harmful environmental influences).

For example, Echinabene. The active substance is a liquid extract. Pharmachologic effect. Herbal immunomodulator

origin. Stimulates predominantly cellular immunity. Increases the number of leukocytes, activates the ability of granulocytes to phagocytose, and promotes the release of cytokines. Indications. The drug is used to increase the body's resistance, for the prevention and treatment of colds, flu, infectious and inflammatory diseases of the nasopharynx and oral cavity.

3. Tonics (have a tonic effect).

4. Hypolipidemics (reduce the level of “bad cholesterol” - LDL).

5. Regulators of body systems and functions.

For example, PLANTEX. Ingredients: fennel fragrance fruit extract with 16% essential oil, glucose, lactose. Plantex is a drug for the correction of digestive disorders in children. The fruits and essential oil of fennel have a digestive stimulant and carminative effect. Stimulate digestion, increasing the secretion of gastric juice and peristalsis. The drug prevents gas formation in the intestines and increases the release of gases and, thus, relieves spasms caused by intestinal flatulence.

6. Anorexigenic drugs - regulators of hunger.

For example, preparations containing fiber.

Parapharmaceuticals with natural enzymes.

Probiotics or eubiotics are dietary supplements that contain live microorganisms and/or their metabolites (products of their metabolism), which have a normalizing effect on the biological activity and composition of the microflora of the gastrointestinal tract.

Types of probiotics

Probiotics mainly improve the health of the gastrointestinal tract. Classic representatives of probiotics are lactic acid bacteria of the genus Lactobacillus and bifidobacteria, which are constantly present in the digestive tract. Microorganisms that occasionally occur in the human intestine are called transient:

* cocci and lactic acid sticks;

* gram-negative Escherichia coli and gram-positive Bacillus bacteria;

* yeast Candida pintolepesii, Saccharomyces;

* mushrooms, including higher ones - Cordiceps, Rizopus, Aspergillus.

Other classifications of dietary supplements are also possible.

According to the form of release, dietary supplements are classified as:

1. Dietary supplements in food form: lollipops, pastilles, jelly, cereals, pastes, balms, teas, syrups, caramels, meal.

For example, E Tea.

Figure 6 - E Tea

Dietary supplement E tea NSP contains burdock root (Arctium lappa), sheep sorrel (Rumex acetosella), American elm bark (Ulmus fulva) and Chinese rhubarb root (Rheum palmatum) (included instead of turkey rhubarb, which is practically not found nowadays. properties Chinese and turkey rhubarb are identical). All medicinal plants in the collection have an immunostimulating, restorative, and tonic effect.

Action:

Strengthens the immune system

Removes waste and toxins

Has anti-inflammatory effect

Helps normalize the function of the digestive system

Has a general strengthening, tonic effect

2. Dietary supplements in dosage form: capsules, tablets, pills, tinctures, extracts, powders, granules, mixtures, oils, infusions, dragees, effervescent tablets.

Based on their sources, dietary supplements are divided into several groups, highlighting those created on the basis of:

Proteins, amino acids and their complexes;

Essential (irreplaceable by the body) lipids;

Carbohydrates and sugars;

Dietary fiber;

Pure substances of macro- and micronutrients;

Natural minerals and mumiyo;

Food and medicinal plants, including pollen;

Processing products of meat and dairy raw materials, by-products, arthropods, amphibians, beekeeping products;

Seafood;

Probiotic microorganisms;

Unicellular algae;

Yeast.

The Institute of Nutrition of the Russian Academy of Medical Sciences has developed a classification based on the effect on the body:

1. Nutraceuticals;

2. Antioxidants;

3. For weight control;

For example, the Turboslim line of drugs.

4. Stimulating the functional activity of individual organs and systems;

For example, Ginkgo Biloba. Herbal product. The action is due to the nature of its influence on metabolic processes in cells, the rheological properties of blood and microcirculation, as well as on the vasomotor reactions of large blood vessels. Improves cerebral circulation and supply of oxygen and glucose to the brain. It has a vasodilating effect and prevents platelet aggregation. Normalizes metabolic processes and has an antihypoxic effect on tissues. Prevents lipid peroxidation and the formation of free radicals in cell membranes. It has a pronounced anti-edematous effect at the level of the brain and in peripheral tissues. In various pathological conditions, it prevents an increase in the proteolytic activity of serum. Indications: geriatrics for attention and/or memory disorders, mental disorders, feelings of fear, dizziness, tinnitus, sleep disorders, general malaise resulting from cerebrovascular disorders.

5. Promoting the healing of bone injuries;

For example, “Calcium D3Nycomed”.

6. Sedative action;

For example, "Persen".

7. Male (for the prevention of prostatitis, restoration of potency, etc.) and female (for the formation of lactation, during menopause, etc.);

For example, Viagra, Leovit Lactagon.

8. Tonic;

Various preparations containing Eleutherococcus.

9. To maintain intestinal function, digestion, bile secretion;

10. General strengthening;

11. Eubiotics. For example, "Eubicor".

1.3. Regulatory basis for the presence of dietary supplements on the pharmaceutical market of the Russian Federation.

In accordance with paragraph 3 of Article 46 of the Federal Law N 184 “On Technical Regulation”, since February 15, 2010, the Decree of the Government of the Russian Federation of December 1, 2009 N 982 “On approval of a unified list of products subject to mandatory certification and a unified list of products, confirmation compliance of which is carried out in the form of acceptance of a declaration of conformity.”

According to part 3 of article 20 Federal Law N184 “On technical regulation”, the adoption of a declaration of conformity (declaration of conformity) is one of the forms of mandatory confirmation of the compliance of products or other objects with the requirements of technical regulations, provisions of standards, codes of practice or terms of contracts.

In their activities, manufacturers inform their clients about the mandatory confirmation of conformity in the form of accepting a declaration for the serial production of their product range. Copies of declarations accompany all shipped products.

The procedure for declaring product conformity is determined by Article 24 of the Federal Law of the Russian Federation of December 27, 2002 N 184-FZ “On Technical Regulation” (as amended on December 30, 2009) and approved by the Government of the Russian Federation of September 7, 1999 N 766 “ The procedure for accepting a declaration of conformity and its registration” (as amended on December 1, 2009). Applicants for declaration of conformity can be those registered on the territory of the Russian Federation entity or an individual as an individual entrepreneur.

Declaration of conformity is a document by which the manufacturer of goods or services confirms that the products they produce or the services they provide comply with the quality and safety requirements established for this product current standards and existing standards.

Products and services that have a Declaration of Conformity have official proof of the appropriate level of quality and inspire consumer confidence.

The declaration of conformity has a validity period and registration number, containing the code of the accredited certification body and the serial number of the declaration itself. Products for which a declaration of conformity has been received are under the control of territorial executive authorities of the Russian Federation as part of supervision over the safety and quality of goods or services.

By Decree of the Government of the Russian Federation No. 988 of December 21, 2000, the “Regulations on State registration new food products, materials and products", in accordance with which the procedure for registering food additives was defined, which meant organic acids and their derivatives used in the food industry, emulsifiers, flavors, acidity regulators, defoamers, antioxidants, dyes, taste and odor enhancers, leavening agents, stabilizers, sweeteners, thickeners, complex and combined functional and technological food additives, biologically active food additives (nutraceuticals, parapharmaceuticals, probiotics - item 8), as well as dietary (therapeutic and preventive) food products (item 4). Thus, there was a regulatory separation of dietary supplements from the group of food additives, but the clarification of “food additives” was retained in their name.

The most important stage in the development of nutrition correction methods, including dietary supplements, was Decree of the Government of the Russian Federation No. 917 in August 1998, which approved the “Concept of state policy in the field of healthy eating population of the Russian Federation for the period until 2005." According to this concept, the basis of the ongoing state policy is the development and implementation comprehensive programs aimed at creating conditions that ensure the satisfaction of the needs of various population groups for rational, healthy nutrition, taking into account their traditions, habits, economic situation and in accordance with the requirements of medical science. The adoption of this program was largely the result of the main violations in the nutritional status of the Russian population proven by many years of research by specialists from the Institute of Nutrition of the Russian Academy of Medical Sciences:

Excessive consumption of animal fats

Excessive intake of sugar and salt

deficiency of polyunsaturated fatty acids

· deficiency of complete animal proteins

deficiency of most vitamins

· deficiency of minerals - calcium, iron, magnesium, potassium, phosphorus

· deficiency of microelements - iodine, fluorine, selenium, zinc

· pronounced deficiency of dietary fiber (fiber) and starch.

The consequences of identified violations of the nutritional status of the Russian population may include:

· progressive increase in the number of adults with reduced body weight and children early age with reduced anthropometric indicators;

· widespread prevalence of various forms of obesity (among people over 30 years old - 55% of the population);

· frequent identification among the population of persons with a reduced immune status, various forms of immunodeficiency, reduced resistance to infections;

· increase in the frequency of nutrition-dependent diseases such as iron deficiency anemia, thyroid diseases, caries, osteoporosis, arthritis;

· an increase in the proportion of people with high risk factors for developing coronary heart disease, hypertension, diabetes mellitus, cerebral atherosclerosis, and cancer.

One of the leading directions of state policy in the field of prevention of nutrition-dependent conditions and diseases is the expansion of the production of biologically active food additives. The “Concept of state policy in the field of healthy nutrition of the population of the Russian Federation for the period until 2005” must be considered as a leading document defining the state’s position in relation to dietary supplements as a group of food products and approving their legal status.

Sanitary and epidemiological rules and regulations SanPiN 2.3.2.1290-03, introduced in 2003, HYGIENIC REQUIREMENTS FOR THE ORGANIZATION OF PRODUCTION AND CIRCUIT OF BIOLOGICALLY ACTIVE FOOD ADDITIVES (BAA) determine that dietary supplements are used as an additional source of food and biologically active substances, incl. h. products that have a general strengthening, mild diuretic, tonic, sedative and other types of effects in various functional conditions, for

· optimization of carbohydrate, fat, protein, vitamin and other types of metabolism in various functional states,

normalization and/or improvement functional state organs and systems human body,

· reducing the risk of diseases,

normalization of the microflora of the gastrointestinal tract,

· as enterosorbents.

It is necessary to highlight the current trend towards mixing medicines on a natural (primarily plant) basis and dietary supplements. It is associated with the inability of the majority of domestic manufacturers to resist the intervention of imported dietary supplements and medicines on the Russian market, as well as the lack of sufficient working capital for the normal promotion of their developments (on a natural basis) to the medicinal market. Moreover, today the structure of manufacturers of Russian dietary supplements is dominated by small enterprises. For example, structures that produce and sell products worth more than $50 thousand per month account for only 35% of the total number of manufacturers. Therefore, a more liberal approach to regulating the market of biologically active food additives compared to the drug market has pushed developers of natural-based drugs to use the opportunity to register their developments under a simplified scheme, as dietary supplements.

The official definition clearly reflects the legal status of dietary supplements as food products, not medicines:

Biologically active food additives (nutraceuticals and parapharmaceuticals) are concentrates of natural or natural-identical biologically active substances intended for direct administration or introduction into food products in order to enrich the human diet with individual biologically active substances or their complexes.

Biologically active food additives (BAA) are obtained from plant, animal or mineral raw materials, as well as by chemical or biotechnological methods. These include enzyme and bacterial preparations (eubiotics), which have a regulating effect on the microflora of the gastrointestinal tract.

In practice, its expanded interpretation has gradually developed, which already allows us to consider dietary supplements as health products. Moreover, many manufacturers of biologically active food supplements have gone even further, omitting the extremely important part of the term - “to food”, and directly positioning them as medicines that provide the possibility of curing a fairly wide range of diseases. As a result of such a substitution of concepts, the conditions were prepared for the penetration of dietary supplements into the drug market, which was fundamentally close, but alien to them.

After such manipulation, manufacturers of dietary supplements were able to form among some consumers of their products the image of a drug that not only improves the quality of life, but also restores health. Thus, along with the possibility of creating a new need among the country’s population, based on the concept of improving the quality of life, manufacturers of dietary supplements did not miss the opportunity to fully use the well-known need for restoring health.

Comparing the above definitions, one can see how the attitude towards dietary supplements is changing - the emphasis on their therapeutic and preventive effect is increasing. The State Sanitary and Epidemiological Supervision Service notes that “the properties of dietary supplements can be divided into three proven actions:

· removal of heavy metal toxins and foreign substances from the body;

· increasing the body’s nonspecific resistance, strengthening the human immune system;

· correction of the deficiency of various microelements, which, taking into account our diet, only dietary supplements can compensate for when used correctly."

It must be emphasized that the use of nutraceuticals is an effective form of primary and secondary prevention of most diseases and their complications, as well as complex treatment of such widespread chronic diseases as obesity, atherosclerosis, reducing the risk of developing cardiovascular diseases, immunodeficiency states, neoplasms, allows:

· it is quite easy and quick to eliminate the deficiency of natural nutrients that are found everywhere in the majority of the Russian population, both adults and children;

· to the maximum possible extent, individualize the nutrition of a particular healthy person depending on the needs that differ significantly not only in gender, age, intensity of physical or mental activity, but also in connection with the genetically determined characteristics of the biochemical constitution, biorhythms, physiological state (pregnancy, lactation, emotional stress, overwork, etc.), as well as environmental conditions of the habitat;

· to satisfy to the maximum extent possible the altered physiological needs for nutrients of a sick or recovering person, as well as, using the principle of metabolic bypass, bypass pathologically damaged parts of the metabolic conveyor;

· increase, by strengthening the elements of enzymatic cell protection, the body’s nonspecific resistance to the effects of adverse factors environment and immunity, especially when living in environmentally disadvantaged regions;

· strengthen and accelerate the binding and removal of foreign and toxic substances from the body;

· Directly change, by influencing the metabolic systems of xenobiotics, the metabolism of individual substances, in particular toxicants.

An independent area of use of dietary supplements-nutraceuticals is therapeutic and functional nutrition. A special area of functional nutrition is sports nutrition.

Parapharmaceuticals, as a rule, are minor (that is, found in small quantities) food components - organic acids, bioflavonoids, glycosides, biogenic amines, regulatory peptides, oligosaccharides, a number of other components that provide regulation (weakening or strengthening) within physiological boundaries of the functional activity of organs and systems, as well as the effect of adaptation of the body to unfavorable conditions. These features allow parapharmaceuticals to be widely used for adjuvant therapy of various diseases.

The daily dose of a parapharmaceutical (or in the case of a composition, its active principle) should not exceed a single therapeutic dose determined when using these substances as medicines. All plants included in parapharmaceuticals must be approved for use in the food industry or as a component of medicinal teas and infusions in accordance with the requirements of the Ministry of Health of the Russian Federation (Guidelines on the procedure for preclinical and clinical studies of drugs of natural origin and homeopathic medicines, 1994).

The physiological level of the active principles of many parapharmaceuticals in the cells and tissues of the body is not known, just as the physiological need for them in an adult healthy person is not known. Moreover, a fairly large number of such dietary supplements have no identified active components at all (for example, extracts from complex complexes of food and medicinal plants, aquatic organisms). In this regard, in a number of cases there is a need to assess their effect on the body as a whole and its individual systems and organs. The main methods for assessing the effectiveness and safety of parapharmaceutical dietary supplements are reflected in the guidelines MUK 2.3.2.721-98 “Determination of the safety and effectiveness of biologically active food additives.”

In many countries around the world, the complex issue of legal regulation of the dietary supplement market is being resolved at the most serious legislative level.

There is a worldwide, global document - CODEX Alimentarius, "Food Code", which regulates many aspects of nutrition. It was adopted in 1962 as a result of the joint efforts of the World Health Organization and the International Food and Agriculture Organization (FAO) and has been revised and supplemented several times since then. This code covers some issues related to the regulation of the production and circulation of dietary supplements.

Let's also consider the state of the dietary supplement market in Russia.

The Russian pharmaceutical market is one of the ten largest pharmaceutical markets in the world. At the end of 2012, Russia took 7th place. The volume of the Russian pharmaceutical market in 2012 amounted to 921 billion rubles. (including VAT) in final consumption prices, which is 12% more than the 2011 figure. In terms of growth rates, Russia shows the third value. The Russian pharmaceutical market is import-oriented. 76% of drugs in monetary terms that are consumed by the population are produced abroad. Therefore, the first places in the ranking of manufacturers are occupied by foreign companies: SANOFIAVENTIS, NOVARTIS. In third place is PHARMSTANDARD - the only domestic manufacturer in the TOP-20 leading players in the Russian pharmaceutical market.

In March 2013, 3,301 trade names of dietary supplements were sold in Russian pharmacies, representing 605 manufacturers.

The graph below shows the volume dynamics commercial market Dietary supplements of Russia from March 2012 to March 2013.

In March 2013, the capacity of the Russian dietary supplement market increased in value terms by 9.3% compared to February and amounted to 2.3 billion rubles. In natural units of measurement, the market increased by 11% and amounted to 29 million packs. It should be noted that for the second month in a row, the growth of the commercial dietary supplement market exceeded the growth of the commercial drug market.

Figure 8 - Dynamics of the Russian dietary supplement market 2012 - 2103

We list in the table below the leading manufacturers of dietary supplements.

Table 1 - TOP 10 manufacturers of dietary supplements by pharmacy sales volume (in value terms) in Russia in February - March 2013.

	Company manufacturer	Share in value sales volume, rub.	Share in physical sales volume, unit. %
February 2013			February 2013	March 2013	February 2013	March 2013
		EVALAR JSC
		RIA PANDA
		AKVION CJSC

		QUEISSER PHARMA GMBH & CO.KG


		POLARIS LLC
		EKOMIR JSC
		POLENS (M) SDN BHD

Source: “Monthly retail audit of the pharmaceutical market of the Russian Federation” DSM Group.

Table 2 - TOP-20 trade names of dietary supplements by pharmacy sales volume (in value terms) in Russia in February - March 2013

	Trade name	Manufacturer	Share in sales value, rub., %
February 2013	March 2013			February 2013	March 2013
		SEALEX FORTE	RIA PANDA
			RIA PANDA
		FITOLAX	EVALAR JSC
		REDUXIN LIGHT	POLARIS LLC
		TONGKAT ALI PLATINUM	POLENS (M) SDN BHD
		TURBOSLIM CLEANING	EVALAR JSC
		DOPPELHERTZ ACTIVE OMEGA-3	QUEISSER PHARMA GMBH & CO.KG
			EVALAR JSC
		INDINOLE CRUCIFLOWER EXTRACT	MIRAKSBIOPHARMA JSC
		NORMOBACT	MEDANA PHARMA TERPOL GROUP S.A.
		MAXILAC	GENEXO SP. Z.O.O
			EVALAR JSC
		TURBOSLIM-NIGHT STRENGTHENED FORMULA	EVALAR JSC
		SUPRADIN KIDS
			AKVION CJSC
		MOONOR FORTE	EVALAR JSC
		OCUWHITE LUTEIN
		CHAMOMILE FLOWERS	ALTAI-FARM LLC
			MERK SELBSTMEDIKATION (DR.REDDY'S PROMOTION)
		TURBOSLIM COFFEE	EVALAR JSC

Structure of the assortment of dietary supplements in a research pharmacy. Results of our own research

Goals and objectives of the thesis:

Diet

Diets for various diseases of organs and systems

Assortment analysis

Assortment indicators

Similar documents

Chapter 1. Dietary supplements and their role in human life

Chapter 1. Dietary supplements and their role in human life

Ø Consist only of natural ingredients (56%).

Ø Much safer than drugs (64%).

Ø Suitable for the treatment of non-severe diseases (66%).

Ø Dietary supplements do not treat, but are used only for prevention/health improvement (75%).

Ø Consumers do not have a clear idea of ​​the cost level of dietary supplements.

Ø Consumers do not know that dietary supplements are a supplement to the diet.

Ø Dietary supplements should be in the diet of every person (63%).

3.2 Strategy for developing an assortment of dietary supplements in a pharmacy organization

Appendix 3

List of main regulatory documents regulating the circulation of dietary supplements in Russia

Vitamin-mineral complexes as sources of natural substances necessary for the body. Dietary supplements, their composition, functions and classification. Development of recommendations for optimizing the range of nutritional supplements in a pharmacy organization.

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Ø Consumers do not have a clear idea of the cost level of dietary supplements.